AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
High tail hall 2 full download 20172/14/2023 ![]() ![]() Integrin α IIbβ 3 has served as an excellent model for the study of integrin biology, and it has become clear that integrin outside-in signaling is highly complex and involves a vast array of enzymes, signaling adaptors, and cytoskeletal components. Ligand binding and integrin clustering subsequently stimulate outside-in signaling, which initiates and amplifies a range of cellular events driving essential platelet processes such as spreading, thrombus consolidation, and clot retraction. Upon platelet activation, inside-out signaling pathways increase the affinity of α IIbβ 3 for fibrinogen and other ligands. Integrin α IIbβ 3 is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis.
0 Comments
Read More
Leave a Reply. |